AlphaVM-Free
A commercial Alpha AXP system emulator from EmuVM, the AlphaVM family of system emulators provide a means to emulate members of the Tsunami family of Alpha based systems from Compaq and HP. Mainly targeted at providing a migration option for existing Alpha systems running OpenVMS or Tru64 UNIX, allowing existing applications to be moved to newer, and potentially more efficient, hardware. A free version of AlphaVM (AlphaVM-Free) was offered as an evaluation and hobbyist product complementing the supported commercial offering (AlphaVM-Pro). Apparently due to licence abuse (see The sad state of Alpha emulators (for OpenVMS) - Raymii.org) the free version has been since replaced with a low cost option (AlphaVM-Basic).
To have a look at the emulator's capabilities and how well it manages to run HP Tru64 UNIX, I've setup a legacy AlphaVM-Free system in a Debian Linux 10 (buster) virtual machine and installed HP Tru64 UNIX 5.1B. Since all versions of AlphaVM are related the other versions will show similar behavior, although there is some additional flexibility with tuning the emulation available in the commercial product.
Note that AlphaVM requires the CMPXCHG16B instruction to be available on the host. In my case this meant I had to update the VirtualBox configuration for the Debian Linux 10 host virtual machine to allow access to this instruction (see virtualbox.org: View topic - hot to enable CMPXCHG16B instruction).